- Ellen Pompeo (Meredith Grey)
- Patrick Dempsey (Derek Shepherd)
- Katherine Heigl (Isobel "Izzie" Stevens
- Justin Chambers (Alex Karev)
- Sandra Oh (Christina Yang)
- T.R. Knight (George O'Malley)
- Chandra Wilson (Miranda Bailey)
- Eric Dane (Mark Sloan)
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